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ea0035p534 | Endocrine tumours and neoplasia | ECE2014

Role of metformin on recurrence-free survival in neuroendocrine tumors

Marciello Francesca , Modica Roberta , Marotta Vincenzo , Ramundo Valeria , Prete Michela Del , Buonomano Pasqualina , Carratu Anna Chiara , de Luca di Roseto Chiara , Picillo Ester , Colao Annamaria , Faggiano Antongiulio

Introduction: Recent data suggest that metformin has antineoplastic properties in different type of cancer. Effects of metformin have never been investigated in neuroendocrine tumors (NET).We aim to determine the role of metformine on recurrence-free survival (RFS) in NET patients.Materials and methods: A retrospective analysis was conducted comparing NET patients with recent diagnosis (<3 year) of diabetes mellitus (with HbA1c...

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ea0014p168 | (1) | ECE2007

Somatostatin receptor immunohistochemistry in neuroendocrine tumors: a proposal of scoring system for clinical characterization and therapy selection

Faggiano Antongiulio , Volante Marco , Pia Brizzi Maria , La Rosa Stefano , Rapa Ida , Ferrero Anna , De Chiara Anna , Righi Luisella , Capella Carlo , De Rosa Gaetano , Dogliotti Luigi , Colao Annamaria , Papotti Mauro

Background: Typing somatostatin receptor (SSTR) expression in neuroendocrine tumors (NETs) is of relevance to target an octreotide-based diagnostic approach and treatment. The expanding use of immunohistochemistry to detect SSTR is to date not paralleled by an accurate methodological setting and standardized interpretation of the results.Objective: A multicentric study was designed to compare SSTR immunohistochemical expression with in vivo scinti...

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Endocrine Abstracts

Role of metformin on recurrence-free survival in neuroendocrine tumors

Somatostatin receptor immunohistochemistry in neuroendocrine tumors: a proposal of scoring system for clinical characterization and therapy selection

BiosciAbstracts